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KMID : 0816120020050010062
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2002 Volume.5 No. 1 p.62 ~ p.67
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Prevalence of Lactose Malabsorption in Children by Breath Hydrogen Test
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Chung Ju-Young
Bae Sun-Hwan
Choi Kwang-Hae
Ko Jae-Sung
Seo Jeong-Kee
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Abstract
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Purpose: The aim of this study was to investigate the age of onset and the prevalence of lactose malabsorption in early childhood in Korea.
Methods: We conducted a study of lactose malabsorption by breath hydrogen test in healthy children aged between 25∼96 months old. Standard lactose loading (2 g lactose/㎏, maximum 40 g) test was done in 129 children and cow’s milk (10 ㎖/㎏) loading in 126 children followed by breath sampling of 60 and 120 minutes after the loading. An
increase above baseline of 20 ppm or more was used as a criteria for positive responses.
Results: The prevalence of lactose malabsorption was 7% in 25∼36 months old, 19% in 37∼48 months old, 35% in 49∼60 months old, 55% in 61∼72 months old, 82% in 72∼84 months old, 80% in 85∼96 months old children. Only 1% of the children showed positive result in breath hydrogen test after the cow’s milk challenge.
Conclusion: The prevalence of lactose malabsorption was increased between 37 months and 60 months of age, reached to adult level of prevalence after 72 months of age. When physiological dose of lactose was used as the challenge, the number of lactose malabsorbers become clinically insignificant.
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KEYWORD
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Lactose malabsorption, Breath hydrogen test, Children
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